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PLENARY 4: Beyond GWAS of insulin resistance: translation of genetic association to function

Prof. Erik Ingelsson
Stanford University

United States of America

Dr. Ingelsson obtained his MD (2000) and PhD (2005) at Uppsala University, Sweden. After internship, he did a residency in general medicine (2003-2006) and took up a postdoctoral research fellowship at the Framingham Heart Study (2006-2007). He moved to Karolinska Institutet (Stockholm, Sweden) in 2007 and was appointed Professor of Cardiovascular Epidemiology in 2010. From 2013-2016, he was a Professor of Molecular Epidemiology at Uppsala University. He was also a Visiting Professor at the Wellcome Trust Centre for Human Genetics at University of Oxford in 2012-2015. Since May 2016, he is Professor of Medicine at Stanford University.

His main area of interest is the link between metabolic disturbances, such as obesity and insulin resistance, and the development of subclinical and clinical cardiovascular disease. His research is translational and interdisciplinary, combining methods from the molecular epidemiology field - such as genomic, metabolomic, transcriptomic, epigenomic and proteomic profiling in large population-based studies - with in vivo and in vitro work to reach new insights into the pathophysiology of cardiovascular disease and related conditions, identification of new biomarkers for improved risk prediction, and discovery of novel targets for drug development.

He has had a leading role in many of the large efforts identifying new loci associated with cardiovascular and metabolic traits, and has extensive experience from research on biomarkers and -omics methods, including development and use of prediction metrics and Mendelian randomization. He has served as PI of numerous –omics efforts in several Swedish cohort studies, including ULSAM, PIVUS, TwinGene and EpiHealth. Since 2014 and on, he has also built a team working with characterization of loci established in GWAS using different functional model systems. He has published over 230 peer-reviewed publications, of which >50 in journals with impact factor over 30. Before relocating to the U.S, he received many European research grants, and now after joining the Stanford faculty in May 2016, he has received his my first NIH grants. He has won several prestigious awards and grants, such as the AHA Trudy Bush Fellowship for Cardiovascular Research in Women’s Health, ERC starting grant, Wallenberg Academy Fellow and the Göran Gustafsson Prize in Medicine in 2015 (to the most successful medical researcher in Sweden under age 45).

On his spare time, he likes to spend time with his family (wife Maria, Hugo, 12 and Alice, 10 years old) and friends; enjoys cooking, but also eating nice food and wine; tries to make his daily running routine; and sings in choirs - amongst others, the San Francisco Symphony Chorus.

Earlier Event: May 29
Lunch in Exhibit Hall / Posters