Plenary 5: Genome and Metagenome Interaction on Lipids Metabolism
May
31
8:30 AM08:30

Plenary 5: Genome and Metagenome Interaction on Lipids Metabolism

Prof. Jingyuan Fu
University Medical Centre Groningen

The Netherlands

Dr. Jingyuan Fu is an associate professor of Bioinformatics in the University Medical Centre Groningen, the Netherlands. She studied Biochemistry (BSc) in China and then developed her scientific career in the fields of systems genetics and integrative genomics. In the Netherlands she gained an MSc in bioinformatics (with distinction) from Wageningen University in 2003 and a PhD cum laude from University of Groningen in 2007. In 2008, Fu joined the University Medical Centre Groningen as a post-doctoral researcher; she was appointed an associate professor in 2015. She has been awarded various funds for her research, including a VENI grant in 2009 and a VIDI in 2014 from the Netherlands Organization of Scientific Research (NWO).

Fu’s research involves multi-dimensional “omics” integrative analysis towards a better understanding of the development of complex diseases, including their genetics, genomics, transcriptomics, and metabolomics. In recent years, her research has expanded to performing population-based gut microbiome analyses. These aim to unravel the host-microbe interactions in the human immune and metabolism systems and the microbiome’s role in the development of metabolic disorders.

 

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May
31
10:00 AM10:00

PS20: Lipid Therapeutic & Protective Potential

10:00-10:30   W-H Schunck (Keynote)         447587         
Therapeutic potential of omega-3 fatty acid-derived epoxyeicosanoids in cardiovascular and inflammatory diseases (30 min)

10:30-10:45   C. Gagnon    443719
Identification of a Novel 20:4 n-3 -Derived 5-Lipoxygenase Product that Inhibits LTB4 Receptor-Dependant Human Neutrophil Activation and Chemotaxis

10:45-11:00   R. Chapkin    428284
Plasma membrane lipid therapy: Disruption of oncogenic KRas nanoscale proteolipid composition by membrane targeted dietary bioactives (MTDB)

11:00-11:15    H-Y. Kim        447599
N-Docosahexaenoylethanolamine enables axon regeneration and improves visual function after optic nerve injury through G-protein coupled receptor 110 activation

11:15-11:30   M. Collins     457366
Brain neurodamage from alcohol: PARP- and PLA2- linked neuroinflammation with prevention by DHA.

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May
31
10:00 AM10:00

PS19: Lipid Metabolism 1

10:00-10:15   R. Brush        448067
Decreased Very Long Chain Polyunsaturated Fatty Acids in Sperm Is Strongly Correlated with Lower Sperm Count and Motility

10:15-10:30    J. Ellis           436176   
Long-Chain Acyl-CoA synthetase 6 deficiency reduces brain docosahexaenoic acid, increases oxidative stress and microglia activation.

10:30-10:45   M. Agbaga              445911
Depletion of Retinal Very Long Chain Fatty Acids Cause Age-Related Rod Photoreceptor Cells Dysfunction    

10:45-11:00   P. Robichaud          443702
PUFA elongation and desaturation following activation of human T cells: ELOVL5 is responsible for fatty acid elongation        

11:00-11:15   S. Basu      432794
Eicosanoids and Pro-inflammatory Factors in Experimental Models of Inflammation

11:15-11:30     I. Mak              445267
Differential effects of long-chain polyunsaturated fatty acids on lipid accumulation and adipokine secretion in mature 3T3-L1 adipocytes

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May
31
10:00 AM10:00

PS18: Dietary Fatty Acid Intake

10:00-10:15   A. Devlin   438638
Dietary Intakes of Arachidonic Acid and Docosahexaenoic Acid and Relationship to Circulating Fatty acid Concentrations in Toddlers

10:15-10:30   L Xie          447370                            
ELOVL2/5 Genetic Variants Interacting with Intake of DHA Modulate n-3 Polyunsaturated Fatty Acids in Han Chinese Breast Milk

10:30-10:45   A. Metherel            442505
Complete assess3: maternal Nutritionment of whole-body n-3 and n-6 PUFA synthesis–secretion kinetics and DHA turnover in a rodent model

10:45-11:00    I. Demonte            421017
Red Blood Cell Trans Fatty Acid Levels in Adults Aged 20-80 years: Results from the Canadian Health Measures Survey 2012-2015

11:00-11:15   B. Delplanque       447950
High intake of dietary Linoleic Acid, compared to SFA or MUFA, limits accretion of preformed DHA to the brain of young rats

11:15-11:30    K. Jackson              419332
Achieving a desirable Omega-3 Index with fish and supplements

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Alexander Leaf Award: Maria Makrides
May
31
11:30 AM11:30

Alexander Leaf Award: Maria Makrides

Standing on the shoulders of giants: great women role models of my career  

Maria Makrides (1,2)
 

1 South Australian Health and Medical Research Institute, Adelaide, Australia
2 School of Medicine, The University of Adelaide, Adelaide, Australia


It’s hard to predict which will be the defining moments and situations of one’s career.  It is only with hindsight that one can look back and evaluate the true impact of a chance meeting with a new colleague at a conference, or that annoying paper reviewer that got you thinking in a different way.

In this presentation, I will reflect on the research studies and situations that offered the greatest learnings and opportunities for career development; they were not always the easy options.  I will share the stories and celebrate the great women role models that showed me the way.


Maria Makrides is the Theme Leader for Healthy Mothers, Babies and Children and Deputy Director at the South Australian Health and Medical Research Institute (SAHMRI), Adelaide, Australia.  As a research dietitian, Maria is committed to improving the nutrition and health of mothers and their babies through the conduct and translation of high quality research.  She has over 230 peer reviewed publications including in the prestigious journals the Lancet, the New England Journal of Medicine, the Journal of the American Medical Association and the British Medical Journal.  Maria’s group has conducted some of the key intervention trials involving omega-3 supplements in perinatal nutrition, and has been recognised with the award of two successive Centres of Research Excellence by the Australian National Health Medical Research Council (NHMRC) Centres: “Foods for Future Australians” (2012-2016) and “Targeted Nutrition to Improve Maternal and Child Health Outcomes” (2017-2022).

Professional Website:
https://www.sahmriresearch.org/our-research/themes/healthy-mothers-babies-children/theme-leader-biography


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PLENARY 6: Omega-3 And Inflammatory Processes: From Membrane To Nucleus And From Bench To Bedside
May
31
1:30 PM13:30

PLENARY 6: Omega-3 And Inflammatory Processes: From Membrane To Nucleus And From Bench To Bedside

Prof. Philip Calder
University of Southampton

United Kingdom
 

Philip Calder is Professor of Nutritional Immunology within the Human Development and Health Academic Unit of the Faculty of Medicine at the University of Southampton in the UK. He has a PhD in Biochemistry from University of Auckland (New Zealand) and a DPhil in Biochemistry from University of Oxford (UK). He is a Registered Nutritionist and a Fellow of both the Royal Society of Biology and the Association for Nutrition. He spent four years as a Nuffield Medical Fellow in the Department of Biochemistry at the University of Oxford (1987-1991) followed by four years as a Lecturer in Biochemistry in that same department (1991-1995). In 1995 he took Lectureship at University of Southampton where he was subsequently appointed to a Readership in Human Nutrition in 1998 and then to a Personal Chair in Nutritional Immunology in 2002. For over 25 years he has conducted research on the metabolism and functionality of fatty acids with an emphasis on the roles of omega-3 fatty acids in immunity, inflammation and cardiometabolic disease. He has received several awards for his work including the Sir David Cuthbertson Medal (1995), the Belgian Danone Institute Chair (2004), the Nutricia International Award (2007), the ESPEN Cuthbertson Lecture (2008), the Muriel Bell Award (2009), the Louisiana State University Chancellor’s Award in Neuroscience and Medicine (2011), the Normann Medal from the German Society for Fat Science (2012), the Ralph Holman Lifetime Achievement Award from the American Oil Chemists’ Society (2015), the British Association for Parenteral & Enteral Nutrition Pennington Lecture (2015), the British Nutrition Foundation Prize (2015) and the Danone International Prize for Nutrition (2016). He has served on many committees of professional societies, including the ISSFAL Board, and was President of ISSFAL 2009-2012. In 2016 he completed a three-year term as Chair of the Scientific Committee of the European Society for Clinical Nutrition and Metabolism (ESPEN) and started a three-year term as President of the Nutrition Society. Professor Calder was Editor-in-Chief of the British Journal of Nutrition from 2006 to 2013 and he is currently an Associate Editor of Clinical Science, Journal of Nutrition, Clinical Nutrition, Lipids, Annals of Nutrition and Metabolism and Nutrition Research. He is a member of the several other Editorial Boards of journals in the nutrition, clinical science and lipidology fields and is Co-Editor of the Lipid metabolism and therapy section of Current Opinion in Clinical Nutrition and Metabolic Care. Professor Calder has over 600 research publications (excluding abstracts), including over 260 peer-reviewed research papers and over 150 review articles in journals. His work has been cited over 22,000 times and he is listed by Thomson Reuters as a Highly Cited Researcher. He was Chair of the 2004 ISSFAL Congress held in Brighton.

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May
31
2:30 PM14:30

PS22: Lipid Metabolism 2 - Clinical Studies

2:30-2:45       T. Mori      421914
The Effect of n-3 Fatty Acids and Coenzyme Q10 Supplementation on Neutrophil Mediators of Inflammation Resolution, Leukotrienes and Myeloperoxidase in Chronic Kidney Disease

2:45-3:00            P. Jackson          436737
Bedtime Supplementation of EPA and DHA Eliminates the Night-Time Diurnal Nadirs of these n-3 PUFA

3:00-3:15            A. Dominichello      448045
Circulating lipid mediators as modifiable prognostic markers for TBI recovery

3:15-3:30            Castro-Marrero              427649
Erythrocyte Omega-3 Fatty Acid Index in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: a pilot cohort study

3:30-3:45            M. Teisen           432763
Oily fish improves attention and well-being in children aged 8-9: The FiSK Junior randomized controlled trial

3:45-4:00            J. Ferguson        419965
Curcumin enhances cholesterol-lowering potential of phytosterols in hypercholesterolemic individuals: a randomized controlled trial

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May
31
2:30 PM14:30

PS23: Ketoneurotherapeutics

2:30-2:45    A. Michael-Titus       446524
A new ketogenic formulation improves functional outcome and reduces tissue loss following traumatic brain injury

2:45-3:15   R. Swerdlow
Feasibility and efficacy data from a ketogenic diet pilot intervention in Alzheimer’s disease

3:15-4:00   S. Cunnane    
Ketones can rescue brain energy metabolism in older people: does this mean they can slow down Alzheimer’s disease?

4:00-4:15   Y. Wang   444301
Effects of Medium- and Long- chain Triacylglycerols on Lipid Metabolism and Gut Microbiota Composition in C57BL/6J Mice

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May
31
2:30 PM14:30

PS21: Oxydized Lipids

2:30-3:00    B. Hammock (Keynote)         
Increasing epoxides of polyunsaturated fatty acids blocks pain and resolves inflammation by modulating the ER stress axis. (30 min)

3:00-3:15    C. Ramsden        447895
Systems approach for discovering linoleic acid derivatives that mediate pain and itch

3:15-3:30     S. Pauls       439761
Anti-inflammatory properties of alpha-linolenic acid and its oxylipins in classically activated macrophages

3:30-3:45     H. Xu            434771
Oxylipin Effects of Aspirin in Adults With Diabetes Mellitus

3:45-4:00   J. Lee           433664
Peroxidation of 4-F4-neuroprostanes induces neurotoxicity in human neuroblastoma cells (SH-SY5Y)

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