PLENARY 1: The Diverse Metabolic Actions of FGF21
8:30 AM08:30

PLENARY 1: The Diverse Metabolic Actions of FGF21

Prof. David Mangelsdorf
University of Texas, Southwestern
United States of America

Dr. David J. Mangelsdorf received his B.S. in Biology and Chemistry from Northern Arizona University in Flagstaff (1981) and his Ph.D. in Biochemistry from the University of Arizona in Tucson (1987). He did his postdoctoral studies at The Salk Institute for Biological Studies. Since 1993 he has been at UT Southwestern, where he currently is Professor and Chair of the Department of Pharmacology, and an Investigator of the Howard Hughes Medical Institute. He holds the Alfred G. Gilman Distinguished Chair in Pharmacology and the Raymond and Ellen Willie Distinguished Chair in Molecular Neuropharmacology, in Honor of Harold B. Crasilneck, Ph.D. He has been a member of the National Academy of Sciences and The Academy of Medicine, Engineering and Science of Texas since 2008.

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10:00 AM10:00

PS03: Nutrition (General Nutrition)

Chairs: C. Smuts /B. Meyer

10:00-10:15      A Minihane     442273
Associations between red blood cell fatty acid status, sex, APOE genotype and cognition: Data from the CANN trial

10:15-10:30        P. Fairbairn       446420
Preliminary analysis suggests a high DHA multi-nutrient supplementation and aerobic exercise produce similar improvements in verbal memory in older females.

10:30-10:45      J Baumgartner  445169
Pre- and postnatal n-3 fatty acid and iron deficiency negatively and irreversibly affect bone development in rats

10:45-11:00        I Nessel    446982          
Optimising long-chain polyunsaturated fatty acid content of donor human milk: a review of current milk banking practices and recommendations for improvement

11:00-11:15       W. Stonehouse      447113
Lipid mediating effects of almonds in overweight and obese participants at risk of type 2 diabetes


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10:00 AM10:00

PS01: Aging and Neurodegenerative Dieseases

Chairs:  N. Salem/ M. Plourde

10:00-10:15       A. Sala-Vila         441491
Phospholipid fatty acid profiling in post-mortem brains across the spectrum of Alzheimer’s disease

10:15-10:30       H. Yassine          434126
Brain Docosahexaenoic Acid uptake in Apolipoprotein E4 carriers: a PET study with [1-11C]-DHA

10:30-10:45       A. Martinsen     440177
The age-associated decrease in brain DHA is only evident in females with an APOE4 genotype: a study in a rodent transgenic model

10:45-11:00       L. Abdullah        448545
APOE4 dependent deficits in brain LPC-DHA and its transporter mfsd2a in Alzheimer’s disease patients

11:00-11:15       C. Song                435255
Anti-inflammatory, anti-oxidative and anti-apoptosical effects of pure and synergistical ratios of docosahexaenoic and eicosapentaenoic acids in Alzheimer’s disease and depression models

11:15-11:30       K. Do                430871
Senescence progression and Aβ cytotoxicity are counter regulated via novel VLC-PUFAs mediators: the elovanoids.

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10:00 AM10:00

PS02: Lipidomics / Metabolomics

Chairs:  H. Kim/ T. Brenna

10:00-10:45       R. Murphy (Keynote)—45 min
Lipidomic Mass Spectrometry: Challenges and Successes

10:45-11:00       N. de Kock          448007
Diagnostic evaluation of steroidomics in a breast cancer cohort in Sweden by convergence chromatography-tandem mass spectrometry

11:00-11:15       A. Sorokin          419736
Identification of novel pro-resolving and inflammatory lipid mediators in human psoriasis skin and blood

11:15-11:30       Y. Wang              447039
Lipidomics reveals association of plasma lysophosphatidylcholine species with adolescent obesity: a pilot study

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Plenary 2: Roles of Pregnancy DHA in Maternal and Child Health and Development
1:30 PM13:30

Plenary 2: Roles of Pregnancy DHA in Maternal and Child Health and Development

Prof. Susan Carlson
Kansas University Medical Center

United States of America

Susan Carlson, PhD, received her bachelor's in home economics at Washington State University in 1969 and her doctorate in nutrition (minors in biochemistry and physiology) from Iowa State University in 1975. She had NICHD postdoctoral fellowships at the University of Wisconsin in the Dept. of Pathology (1975-1977) and at the University of South Florida in the Dept. of Pediatrics (1978-1979).

A faculty member in several medical school departments of pediatrics, mainly in divisions of newborn medicine from 1979-1997, Carlson rose through the ranks to professor in the Departments of Pediatrics, Obstetrics and Gynecology and Biochemistry at the University of Tennessee, Memphis. Her major research interest was on the effects of fatty acids that compose a large percent of brain membranes and found in human milk but not in vegetable oils typically used in the production of U.S. infant formulas.

Carlson moved to the University of Missouri Kansas City in 1997 and to the University of Kansas Medical Center in 1999. While at these institutions, she has continued intervention studies of docosahexaenoic acid (DHA) and arachidonic acid (AA) supplementation of infants and branched out into studies of DHA- supplemented pregnant women. The latter studies have been done in collaboration with the research team led by John Colombo, PhD, at the University of Kansas through the Maternal and Child Nutrition and Development Laboratory.

Carlson and Colombo have been active in large clinical trials studying infant DHA supplementation and DHA administered to women entering their second trimester of pregnancy. The goal of these trials is to evaluate the effect of DHA provided pre- and postnatally on visual development and behavior of infants, toddlers and, eventually, preschoolers.

Her work having been recognized nationally and internationally, Carlson receives numerous invitations to conferences. In 2002, DHA and AA were added to U.S. infant formulas. In Nov. 2002, she was made an honorary member of the American Dietetic Association in recognition for her pioneering work in identifying DHA as a conditionally essential nutrient for developing infants. Carlson received the 2008 March of Dimes Agnes Higgins Award for outstanding achievement in the field of maternal-fetal nutrition at the American Public Health Association meeting in San Diego, October 2008.

Since 2002, Carlson has taken an active role in the education of U.S. pediatricians, obstetricians, nurses and dietitians about the roles of DHA in maternal and infant health. As part of her role, she has been involved nationally and internationally in evaluating the quality of evidence and establishing best practice guidelines for intake of DHA by infants and pregnant women.

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2:30 PM14:30

PS04: Brain Fatty Acid Uptake & Lipid Profile

Chairs: M. Lagarde/ R. Bazinet

2:30-2:45            P. Subbaiah       457118
Efficient delivery of dietary DHA to the brain, and improvement of memory through lysophosphatidylcholine

2:45-3:00            R. Bazinet           464288
How docosahexaenoic acid enters the brain: A model unifying plasma lysophospholipid and unesterified pools.

3:00-3:15            H. Nacir               447386
DHA bioavailability from the structured phospholipid 1-acetyl,2-docosahexaenoyl-glycerophosphocholine (AceDoPC®) in humans.  

3:15-3:30            V. Giuliano         447685
Applying stable carbon isotopic analysis at the natural abundance level to determine the origin of brain docosahexaenoic acid

3:30-3:45            R.J. Lacombe     447964
Natural abundance carbon isotopic analysis indicates equal contribution of local synthesis and plasma uptake to palmitic acid levels in mouse brain.

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2:30 PM14:30

PS06: Maternal & Infant Nutrition489308

Chairs: R. Gibson/M. Suh

2:30-2:45     R. Gibson    489308
Docosahexaenoic Acid and Bronchopulmonary Dyplasia in Preterm Infants - The N3RO Trial

2:45-3:00    J. Colombo   445618
Long-Term Outcomes of Prenatal DHA Supplementation

3:00-3:15     K. Gustafson       439580
Docosahexaenoic acid supplementation during pregnancy affects offspring brain function at age 5 years 

3:15-3:30    B. Feltham   447734
DHA supplementation during prenatal ethanol exposure reduces oxidative stress in fetal liver

3:30-3:45   L. Lauritzen  432877
Erythrocyte polyunsaturated fatty acids, FADS and PPARG2 single-nucleotide polymorphisms are associated with plasma lipid profile in 9-month-old infants

3:45-4:00   C. Smuts       447546
Efficacy of novel small-quantity lipid-based nutrient supplements in improving long-chain polyunsaturated fatty acid status in South African infants: A randomized, controlled trial

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2:30 PM14:30

PS05: Cardiovascular

Chairs: W. Harris/ A. Devlin

2:30-2:45      C. von Schacky        445242
Fatty acid risk score improves risk prediction in primary and secondary prevention compared to established risk prediction algorithms

2:45-3:00      L. Liu           447555
EPA and DHA Protection Against Left Ventricular Hypertrophy: MESA

3:00-3:15   W. Harris      426011
Erythrocyte Long-Chain Omega-3 Fatty Acid Levels are Inversely Associated with Mortality and with Incident Cardiovascular Disease: the Framingham Heart Study

3:15-3:30    M. Marklund             433119
Biomarkers of dietary omega-6 fatty acids and incident cardiovascular disease and mortality: a pooled analysis of 30 cohort studies

3:30-3:45    P. Howe       447385
Gender dependent effects of fish oil supplementation on cerebrovascular responsiveness

3:45-4:00     J. Glatz        446717
Identification of v-ATPase as an intracellular lipid sensor in the heart

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4:45 PM16:45

PS08: Inflammation and Allergy

Chairs: P. Calder/ R. Shaikh

4:45-5:00           Y. Wan                 441562 The Protective Effects of a Lipid Extract from Hard-Shelled Mussel (Mytilus Coruscus) on Intestinal Integrity after Lipopolysaccharide Challenge in Mice

5:00-5:15         K. Wierenga         424624
Percent omega-3 in highly unsaturated fatty acids (HUFAs) is a predictor of disease outcomes in an environmental toxicant-triggered lupus mouse model

5:15-5:30    M. Crouch   425506
Docosahexaenoic acid improves the decrement in antibody production of obese mice upon influenza infection through a mechanism mediated by 14-HDHA

5:30-5:45   J. Pestka        441686
Docosahexanoic Acid Consumption Prevents Toxicant-Triggered Ectopic Lymphoid Structure Development and Autoantibody Responses in Lupus-Prone Mice

5:45-6:00   C.  Souza        446023
Palmitoleic acid attenuated the high fat diet induced liver inflammation

6:00-6:15   K. Hadley    448127
Supplementing dams with both arachidonic and docosahexaenoic acid has beneficial effects on growth and immune development in offspring

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4:45 PM16:45

PS07: Neuroscience

Chairs: N. Bazan/K. Lin

4:45-5:15            N. Bazan (Keynote)         441812
The elovanoids: a novel class of mediators that arise from elongated omega-3 fatty acids and target neuronal pro-homeostatic signaling hubs (30 min)

5:15-5:30            M. Neuringer     447228
Dietary deficiency of n-3 fatty acids and macular pigment carotenoids: Update on a nonhuman primate model of retinal aging and macular degeneration

5:30-5:45            A. Nadjar            429596
Polyunsaturated fatty acids tune microglial shaping of neuronal circuits in the developing brain

5:45-6:00            A. Desai            448408
Effect of brain DHA status and exogenous synaptamide on injury outcome in a mouse model of repeated brain injury

6:00-6:15            K. Lin     427336
Palmitic acid methylation confers neuroprotection in cerebral ischemia

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